EVOXACT Ceftriaxone (INN) /ˌsɛftraɪˈæksoʊn/ is an antibiotic useful for the treatment of a number of bacterial infections. It is a third-generation cephalosporin. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positivebacteria and expanded Gram-negative coverage compared to second-generation agents. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone sodium is marketed by Hoffmann-La Roche Ceftriaxone is used to treat a wide variety of serious infections caused by organisms that are resistant to most other antibiotics. It is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis caused by pneumococci, meningococci, Haemophilus influenzae, and susceptible enteric gram-negative rods, but not Listeria monocytogenes. Other uses included the treatment of acute bacterial otitis media, skin and skin structure infections, bone and joint infections,gonorrhea, intra-abdominal and urinary tract infections, pelvic inflammatory disease (PID), and bacterial septicemia. It also approved to be used in surgical (perioperative) prophylaxis.