Colaxo

ETARICOXIB/THIOCHOLCHICOSIDE

Indications for Etoricoxib + Thiocolchicoside

  • Rheumatoid arthritis
  • Osteoarthritis
  • 3.Ankylosing spondylitis
  • 4.Chronic low back pain
  • 5.Acute pain and gout
  • Interactions for Etoricoxib + Thiocolchicoside N/A
  • Typical Dosage for Etoricoxib + Thiocolchicoside N/A
  • Schedule of Etoricoxib + Thiocolchicoside N/A
  • Storage Requirements for Etoricoxib + Thiocolchicoside N/A
  • Effects of Missed Dosage of Etoricoxib + Thiocolchicoside N/A
  • Effects of Overdose of Etoricoxib + Thiocolchicoside N/A

Colaxo

About Etoricoxib NSAID, selective COX-2 inhibitor, Analgesic,Anti-inflammatory,Antiarthritic. Mechanism of Action of Etoricoxib This NSAID is a selective COX2 inhibitor (blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation). This inhibition results the analgesics and anti-inflammatory action peripherally Pharmacokinets of Etoricoxib Absorption- Well absorbed after administration Distribution- Widely distributed in the body Metabolism- Metabolized in the liver to its metabolites Excretion- Excreted through urine and feces Onset of Action for Etoricoxib 24 min Duration of Action for Etoricoxib 24 hrs Half Life of Etoricoxib Its plasma half life is 22 hrs Side Effects of Etoricoxib

  • Dry mouth
  • Taste disturbances
  • Mouth ulcers
  • Flatulence
  • Constipation
  • Appetite and weight changes
  • Chest pain
  • Fatigue
  • Paresthesia
  • Myalgia
  • Rash
  • Blurred vision
  • Insomnia
  • Muscle cramps
  • Ulceration of the stomach or intestine
  • Cold or flu-like symptoms
  • Dizziness
  • Excessive fluid retention in the body tissues, resulting in swelling (oedema)
  • Epistaxis
  • Difficulty in breathing (dyspnoea)
  • Weakness or loss of strength (asthenia)
  • High blood pressure (hypertension)
  • Anxiety
  • Headache

Contra-indications of Etoricoxib

  • Hypersensitivity to the drug
  • Hyper sensitivity to other NSAID
  • Active peptic ulceration
  • Inflammatory bowel disease
  • Severe congestive heart failure

Special Precautions while taking Etoricoxib

  • Allergic disorders
  • Renal impairment
  • Cardiac diseases
  • Hepatic impairment

Pregnancy Related Information Contraindicated Old Age Related Information Use with caution Breast Feeding Related Information Contraindicated Children Related Information Use with caution Indications for Etoricoxib

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Acute gouty Arthritis

Interactions for Etoricoxib Anticoagulants : May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding. ACE inhibitors : Antihypertensive effects of captopril may be blunted or completely abolished by etoricoxib. b-Blockers : Antihypertensive effect may be blunted. Cyclosporine : Nephrotoxicity of both agents may be increased. Digoxin : Serum digoxin levels may be increased by ibuprofen and etoricoxib. Hydantoins : Serum hydantoin levels increased resulting in increased pharmacological and toxic effects. Lithium : Serum lithium levels may be increased. Loop diuretics : Decreased effects. Methotrexate : Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased. Salicylates : displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects. Sympathomimetics : Rofecoxib coadministration may result in increased blood pressure. Thiazide diuretics : Naproxen and etoricoxib may cause decreased antihypertensive and diuretic action. Typical Dosage for Etoricoxib Oral- Adults- Osteoarthritis- 60 mg once daily Rheumatoid Arthritis- 90 mg once daily Acute gouty Arthritis-120 mg once daily Schedule of Etoricoxib N/A Storage Requirements for Etoricoxib Store at room temperature away from moisture and heat Effects of Missed Dosage of Etoricoxib Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. Effects of Overdose of Etoricoxib Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Thiocolchicoside

bout Thiocolchicoside A GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant. Mechanism of Action of Thiocolchicoside Thiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms. Pharmacokinets of Thiocolchicoside
Side Effects of Thiocolchicoside:

  • Diarrhoea
  • Gastralgia
  • Nausea
  • Vomiting
  • Drowsiness
  • Anaphylactic reaction

Contra-indications of Thiocolchicoside 1. Contraindicated in patients with hypersensitivity to the drug Special Precautions while taking Thiocolchicoside 1. Use with caution in patients with diarrhea Pregnancy Related Information Contraindicated Old Age Related Information Use with caution Breast Feeding Related Information Contraindicated Children Related Information Use with caution Indications for Thiocolchicoside Painful muscle spasm associated with

  • Degenerative vertebral disorders
  • Torticollis
  • Dorsal pain
  • Low back pain
  • Traumatological disorders
  • Neurological disorders

Interactions for Thiocolchicoside No known interactions with other drugs. Typical Dosage for Thiocolchicoside Adult- Oral- 4mg twice a day for 5 to 7 days. Intramuscular- 4mg twice a day for 3 to 5 days. Schedule of Thiocolchicoside N/A Storage Requirements for Thiocolchicoside N/A Effects of Missed Dosage of Thiocolchicoside Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. Effects of Overdose of Thiocolchicoside Give symptomatic and supportive treatment. Etoricoxib + Thiocolchicoside is a generic medicine name and there are several brands available for it. Some of the brands for etoricoxib + thiocolchicoside might be better known than etoricoxib + thiocolchicoside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etoricoxib + thiocolchicoside in stock, you can ask for one of the branded alternatives for etoricoxib + thiocolchicoside.